Friday, April 5, 2013

1304.1409 (M. V. Koroteev et al.)

Fragmentation dynamics of DNA sequence duplications    [PDF]

M. V. Koroteev, J. Miller
Motivated by empirical observations of algebraic duplicated sequence length distributions in a broad range of natural genomes, we analytically formulate and solve a class of simple discrete duplication/substitution models that generate steady-states sharing this property. Continuum equations are derived for arbitrary time-independent duplication length source distribution, a limit that we show can be mapped directly onto certain fragmentation models that have been intensively studied by physicists in recent years. Quantitative agreement with simulation is demonstrated. These models account for the algebraic form and exponent of naturally occuring duplication length distributions without the need for fine-tuning of parameters.
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